GIANNINI , Barbara

Abstract Information and Communication Technology (ICT) tools can efficiently support clinical research by providing means to collect automatically huge amount of data useful for the management of clinical trials conduction. Clinical trials are indispensable tools for Evidence-Based Medicine and represent the most prevalent clinical research...

A validation procedure to evaluate the optimal number of clusters in a toxic activity data set using automatic classification by crisp partitioning clustering is here presented. The clustering procedures used are based on either the Kohonen, SOM, and kmeans joined algorithms. The clustering validation method consists in the use of an index...

Background: Retention in care (RC) is a key feature of the cascade of continuum of care that moves from HIV testing to linkage to care, engagement in care and RC. RC play an important role in achieving and maintaining therapeutic success and is crucial for reduction of HIV transmission. The aim of this study was to evaluate the rate of RC in...

Methods All patients followed by our HIV outpatients service who started a first or an early switch regimen in 2014 have been enrolled. Demographic and epidemiological data were recorded. Each HIV treatment receives a score resulting from combining its relevance (according to Italian guidelines) and its related monthly cost. The most...

Objectives: Chronic hepatitis C virus (HCV) is a leading cause of hospitalization and death in populations coinfected with human immunodeficiency virus (HIV). Sofosbuvir (SOF) is a pan-genotypic drug that should be combined with other agents as an oral treatment for HCV. We performed a 5-year horizon budget impact analysis of SOF-based regimens...

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Background: In the last twenty years routine T CD4+ lymphocyte (CD4) cell count has proved to be a key factor to determine the stage of HIV infection and start or discontinue of prophylaxis for opportunistic infections. However, several studies recently showed that in stable patients on cART a quarterly CD4 cell count monitoring results in...

OBJECTIVES: Chronic HCV is a leading cause of hospitalization and death in populations coinfected with HIV in Italy. Sofosbuvir (SOF) is a pan-genotypic drug, which can be used alone or combined with other agents (e.g.Simeprevir,Daclatasvir, Ledipasvir) as oral treatment for HCV, with different price levels. We performed a 5 year-horizon budget...

INTRODUCTION: The introduction of combined antiretroviral treatment (cART) has reduced HIV-associated morbidity and mortality, and changed the patients' perspective of life. As a result, Health Related Quality of Life (HRQOL) has become a crucial clinical issue. OBJECTIVE: Assessment of HRQOL in a sample of Italian patients from IANUA...

OBJECTIVES To understand the relationship between socio-demographic variables, clinical factors, highly active anti-retroviral therapy (HAART) and health related quality of life (QoL) in HIV-infected individuals participants in the IANUA multicenter study. METHODS Data relating to patients with HIV infection admitted to 3 infectious disease...

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The aims of this study were to assess the Health Related Quality of Life (HRQoL) of People Living with HIV/AIDS (PLWHA) who attend outpatient services in Genoa, Italy, and to evaluate the relationship between HRQoL and clinical factors, primarily: CD4+ cell count, viral load and HIV-Hepatitis C Virus (HCV) coinfection. A cross-sectional study...

Even in the era of highly active antiretroviral therapy (HAART), HIV-infected subjects are at higher risk of complications from vaccine-preventable diseases than those uninfected. Despite the current national and international guidelines strongly recommend that these patients should been immunized, the available data indicate sub-optimal...

The number of HIV positive patients is constantly growing, and, nowadays the expense for the public healthcare sector for their treatment is thus increasing as well. For this reason, a cost effectiveness study at a regional level was necessary, to identify possible inefficiencies in relation to expenditure. Therefore, a new clinical trial,...