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2000 (v1)PublicationUploaded on: March 31, 2023
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1998 (v1)Publication
Asymmetrized tris(hydroxymethyl)methane (THYM*) is a new chiral building block easily accessible in both enantiomeric forms by a chemoenzymatic methodology. The presence of three synthetically equivalent masked hydroxymethyl groups and a high degree of latent symmetry (C3v) makes this synthon very versatile in synthetic applications. This...
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1993 (v1)Publication
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1995 (v1)Publication
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1997 (v1)Publication
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1999 (v1)Publication
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2002 (v1)Publication
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2001 (v1)Publication
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2003 (v1)Publication
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2000 (v1)Publication
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2002 (v1)Publication
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1998 (v1)Publication
New "lactendiynes", characterized by the fusion at C-4 and N-1 of a β-lactam with a hydroxylated 10-membered cyclic enediyne, were synthesized. Studies on their reactivity have shown that this type of fusion with the azetidinone represents a sufficient "safety-catch" against cycloaromatization. These compounds are relatively reactive toward...
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2001 (v1)Publication
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1999 (v1)Publication
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2000 (v1)Publication
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2003 (v1)Publication
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2002 (v1)Publication
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1995 (v1)Publication
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2002 (v1)Publication
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1995 (v1)Publication
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2006 (v1)Publication
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1996 (v1)Publication
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1994 (v1)Publication
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1993 (v1)Publication
4-Unsubstituted 2-azetidinones 3a,b, which are useful intermediates for the synthesis of carbapenem antibiotics, have been enantiospecifically and diastereoselectively prepared starting from asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*) 4. a new chiral building block obtained through biological methods. The key steps are the highly...
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1986 (v1)Publication
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