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GALMARINI , Carlos María

Last name: GALMARINI

First name: Carlos María

October 2, 2020 (v1)

Publication

Metadata-only

The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability

Tumini, Emanuela Herrera Moyano, Emilia San Martín Alonso, Marta

R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer cells. Accordingly, growing evidence suggests that R-loops may also be related to cancer. Here we show that R-loops play an important role in the cellular response to trabectedin (ET743), an anticancer drug from marine...

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