CONTEXT: Gastroesophageal reflux disease (GERD) is a chronic, relapsing disease with symptoms that have negative effects on daily life. Two treatment options are long-term medication or surgery. OBJECTIVE: To evaluate optimized esomeprazole therapy vs standardized laparoscopic antireflux surgery (LARS) in patients with GERD. DESIGN, SETTING,...
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2011 (v1)PublicationUploaded on: March 27, 2023
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2017 (v1)Publication
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Uploaded on: March 27, 2023 -
2017 (v1)Publication
Background: Proton pump inhibitors and laparoscopic anti-reflux surgery (LARS) offer long-term symptom control to patients with gastro-oesophageal reflux disease (GERD). Aim: To evaluate the process of 'normalisation' of the squamous epithelium morphology of the distal oesophagus on these therapies. Methods: In the LOTUS trial, 554 patients...
Uploaded on: March 27, 2023