GARBARINO S.

We introduce a theoretical framework for estimating, comparing and interpreting mechanistic hypotheses on long term protein propagation across brain networks in neurodegenerative disorders (ND). The model is expressed within a Bayesian non-parametric regression setting, where mechanisms of protein dynamics are inferred by means of gradient...

Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the second of a series of two that deal with the problem of tracer coefficient estimation via compartmental modelling in an...

In this paper we propose a new algorithm to optimize the parameters of a compartmental problem describing tumor hypoxia. The method is based on a multivariate Newton approach, with Tikhonov regularization, and can be easily applied to data with diverse statistical distributions. Here we simulate [18F]-fluoromisonidazole Positron Emission...

Models of misfolded proteins (MP) aim at discovering the bio-mechanical propagation properties of neurological diseases (ND) by identifying plausible associated dynamical systems. Solving these systems along the full disease trajectory is usually challenging, due to the lack of a well defined time axis for the pathology. This issue is addressed...

Sleep occupies a third of our life and is a primary need for all animal species studied so far. Nonetheless, chronic sleep restriction is a growing source of morbidity and mortality in both developed and developing countries. Sleep loss is associated with the subjective feeling of sleepiness and with decreased performance, as well as with...

Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the first of a series of two that deal with the problem of tracer coefficient estimation via compartmental modelling in an...

In this work we deal with parametric inverse problems, which consist in recovering a finite number of parameters describing the structure of an unknown object, from indirect measurements. State-of-the-art methods for approximating a regularizing inverse operator by using a dataset of input-output pairs of the forward model rely on deep learning...

The World Health Organization supports tools and initiatives in Health Impact Assessment to dynamically improve health and well-being across different sectors. Human Impact Assessment (HuIA) is a relatively new concept. It describes an integrated process that encompasses both Health Impact Assessment and Social Impact Assessment and is used to...

Policemen are workers exposed to risk from both shiftwork and delicate tasks. This study aims to investigate sleep habits, prevalence of sleep disturbance, sleepiness and hypnotic drug intake in the whole population of Italian State Policemen working in the Genoa district. Italian literature is completely lacking of such data. The study has...

Aims. This study is aimed at providing the first demonstration of STIX Fourier-transform X-ray imaging using semi-calibrated (amplitude-only) visibility data acquired during Solar Orbiter's cruise phase. Methods. We used a parametric imaging approach whereby STIX visibility amplitudes are fitted by means of two non-linear optimization methods:...

Circadian mechanisms and the sleep-wakefulness rhythms guarantee survival, adaptation, efficient action in everyday life or in emergencies and well-being. Disordered circadian processes at central and/or cellular levels, sleep disorders, and unhealthy wakefulness/ sleep rhythms can impair the physiological circadian organization and result in...

The aim of this study was to evaluate the effects of shiftwork on sleepiness, sleep disorders and sleep related accidents in a population of policemen. Data concerning age and physical characteristics, working conditions, sleep problems and accidents were collected by a questionnaire. Sleepiness was evaluated by the Epworth Sleepiness Scale...

Sleep disorders and daytime sleepiness are the most frequent disturbances reported by shift-workers. Sleepiness and fatigue can increase the risk of human errors and accidents especially during night work. In order to evaluate the time distribution and the possible role of sleepiness on road accidents in policemen on shiftwork on highway...