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April 8, 2021 (v1)PublicationUploaded on: December 4, 2022
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September 16, 2020 (v1)Publication
Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis. Various studies have shown that mitochondria play a central role in these processes because of the ability of this organelle to modify cell metabolism, allowing survival...
Uploaded on: March 27, 2023 -
March 22, 2018 (v1)Publication
NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation of these genes in tumors is common, allowing aberrant Notch pathway activation and tumor progression. However, some known differences between NUMB and NUMBL have raised unanswered questions regarding the redundancy and/or...
Uploaded on: March 27, 2023 -
February 22, 2018 (v1)Publication
Inflammation is a complex defensive response activated after various harmful stimuli allowing the clearance of damaged cells and initiating healing and regenerative processes. Chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a cargo protein that transports membrane...
Uploaded on: March 27, 2023 -
April 10, 2017 (v1)Publication
Otto Warburg observed that cancer cells derived their energy from aerobic glycolysis by converting glucose to lactate. This mechanism is in opposition to the higher energy requirements of cancer cells because oxidative phosphorylation (OxPhos) produces more ATP from glucose. Warburg hypothesized that this phenomenon occurs due to the...
Uploaded on: March 27, 2023 -
April 24, 2018 (v1)Publication
Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a small protein localized to membranes with a restricted pattern of expression in adult tissues. However, its...
Uploaded on: March 27, 2023 -
April 20, 2023 (v1)Publication
NUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one daughter cell inheriting NUMB and the other inheriting its antagonist, NOTCH. NUMB has been proposed as a polarizing agent...
Uploaded on: April 23, 2023 -
April 12, 2022 (v1)Publication
Breast cancer is the most frequent cancer in women and the second most frequent overall after lung cancer. Although the 5-year survival rate of breast cancer is relatively high, recurrence is also common which often involves metastasis with its consequent threat for patients. DNA methylation-derived databases have become an interesting...
Uploaded on: December 4, 2022 -
December 1, 2023 (v1)Publication
Construcción génica que codifica para el citocromo c y procedimiento de obtención. Se describe una construcción génica que comprende (i) una primera secuencia de ácido nucleico que comprende una secuencia de nucleótidos que codifica para un cito cromo c, y (ii) una segunda secuencia de ácido nucleico que comprende una secuencia de nucleótidos...
Uploaded on: December 3, 2023 -
April 25, 2022 (v1)Publication
This work proposes a methodology to identify genes highly related with cancer. In particular, a multi-objective evolutionary algo rithm named CANGAR is applied to obtain quantitative association rules. This kind of rules are used to identify dependencies between genes and their expression levels. Hierarchical cluster analysis, fold-change...
Uploaded on: March 25, 2023