GARCÍA MARTÍN , María De Gracia

CONCLUSIONES: 1. Se pone a punto un procedimiento para obtener N-diacilvinilderivados ("enaminonas") de aminoazúcares, basado en la reacción de transenaminación entre un N-diacilvinilderivado de la anilina y el aminoazúcar. Se trata de un proceso reversible que está desplazado en el sentido de la enaminona de la amina más básica...

Ministerio de Economía y Competitividad MAT2012- 38044-C03-01

A simple redox amphiphilic tri-block copolyurethane capable of assembling in the form of polymersome has been easily synthesized. Thus, the hydrophobic core is constituted by a central block containing multiple disulfide linkages, and the hydrophilic segments are formed by poly(ethylene glycol) methyl ether (mPEG2000). The disulfide-containing...

The capacity of redox D-mannitol-based polyurethanes to modulate the glutathione response under physiological conditions, as well as their effectiveness for sustained and site-specific drug release in the gastrointestinal tract (GIT), have been demonstrated in previous studies. Based on those promising results, our attention has now been drawn...

The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must...

NMR, ATR-FTIR and Mass Spectra of small molecules and monomers: {1-[3,5-bis(trifluoromethyl)phenyl]-3-cyclohexylthiourea} (TU) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS 3-(Prop-2-yn-1-ylthio)-propane-1,2-diol (1) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS, ESI-HRMS 4-[(Prop-2-yn-1-ylthio)methyl]-1,3-dioxolan-2-one (2) ...

An increase in resistance to key antibiotics has made the need for novel treatments for the gastric colonization of Helicobacter pylori (H. pylori) a matter of the utmost urgency. Recent studies tackling this topic have focused either on the discovery of new compounds to ameliorate therapeutic regimes (such as vonoprazan) or the synthesis of...

The main objective of the present paper has been the development and study of two new biodegradable polyurethanes, PU(dithiodiethanol-DTDI) and PU[(iPr)Man-DTDI], to be used as sustained matrix forming excipients. Furthermore, their capacity to act as excipient for colon drug delivery systems has been evaluated. Thus, SeDeM diagrams have been...