Salmonella enterica serovar Typhimurium posee un plásmido de gran tamaño (93 Kb) llamado plásmido de virulencia o pSLT. Dicho plásmido contiene el locus spv, esencial para la infección sistémica en roedores. El plásmido fue presumiblemente adquirido por el hospedador ancestral de Salmonella mediante conjugación. En la mayoría de las estirpes...
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November 27, 2014 (v1)PublicationUploaded on: December 4, 2022
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June 6, 2023 (v1)Publication
Up to 25% of patients with long COVID experience persistent night sweats. However, in most cases they remain untreated until they disappear on their own. Since SARS-CoV-2 is known to disrupt glucose homeostasis, we hypothesized that impaired mitochondria would result in faster glycogen depletion at night due to reduced ATP production yield,...
Uploaded on: June 7, 2023 -
March 30, 2022 (v1)Publication
Bacteriophages are ubiquitous in nature and their use is a current promising alternative in biological control. Multidrug resistant (MDR) bacterial strains are present in the livestock industry and phages are attractive candidates to eliminate them and their biofilms. This alternative therapy also reduces the non-desirable effects produced by...
Uploaded on: December 4, 2022 -
October 22, 2019 (v1)Publication
The Glutamate Receptor Ionotropic NMDA-Associated Protein 1 (GRINA) belongs to the Lifeguard family and is involved in calcium homeostasis, which governs key processes, such as cell survival or the release of neurotransmitters. GRINA is mainly associated with membranes of the endoplasmic reticulum, Golgi, endosome, and the cell surface, but its...
Uploaded on: March 25, 2023 -
February 26, 2016 (v1)Publication
BALB/c mice were infected with two Salmonella enterica serovar Typhimurium strains, one of which lacked the virulence plasmid. Transconjugants were found at high frequencies in the mouse feces and at low frequencies in the liver and the spleen, suggesting that mating occurred in the gut. Laboratory conditions that mimic those of the small...
Uploaded on: December 4, 2022 -
May 27, 2021 (v1)Publication
The increasing clinical importance of infections caused by multidrug resistant Acinetobacter baumannii warrants the development of novel approaches for prevention and treatment. In this context, vaccination of certain patient populations may contribute to reducing the morbidity and mortality caused by this pathogen. Vaccines against...
Uploaded on: March 25, 2023 -
April 22, 2019 (v1)Publication
Pseudomonas aeruginosa is a common Gram-negative opportunistic pathogen that is intrinsically resistant to a wide range of antibiotics. The development of a broadly protective vaccine against P. aeruginosa remains a major challenge. Here, we used an attenuated strain of Salmonella enterica serovar Typhimurium as a vehicle to express P....
Uploaded on: December 4, 2022 -
March 1, 2016 (v1)Publication
Exposure to bile induces curing of the virulence plasmid in Salmonella enterica serovar Typhimurium (pSLT). Disruption of the ccdB gene increases pSLT curing, both spontaneous and induced by bile, suggesting that the pSLT ccdAB genes may encode a homolog of the CcdAB addiction module previously described in the F sex factor. Unlike the F sex...
Uploaded on: December 4, 2022 -
January 25, 2024 (v1)Publication
The global emergence of multidrug resistant Acinetobacter baumannii has reduced the number of clinically available antibiotics that retain activity against this pathogen. For this reason, the development of novel prevention and treatment strategies for infections caused by A. baumannii is necessary. Several studies have begun to characterize...
Uploaded on: January 27, 2024 -
January 25, 2024 (v1)Publication
Antimicrobial susceptibility testing is essential for guiding the treatment of many types of bacterial infections, especially in the current context of rising rates of antibiotic resistance. The most commonly employed methods rely on the detection of phenotypic resistance by measuring bacterial growth in the presence of the antibiotic being...
Uploaded on: January 27, 2024 -
February 27, 2024 (v1)Publication
Acinetobacter baumannii can acquire resistance to colistin via complete loss of lipopolysaccharide (LPS) biosynthesis due to mutations in the lpxA, lpxC and lpxD genes. However, although colistin is increasingly being used for the treatment of multidrug resistant infections, very few A. baumannii clinical isolates develop colistin resistance...
Uploaded on: March 3, 2024