GARCÍA DE OYA , Inés

Durante la división celular es fundamental asegurar el correcto reparto del material genético entre las células hijas resultantes. Errores en este proceso pueden dar lugar a problemas como la aneuploidía, una condición en la que la célula adquiere un número incorrecto de cromosomas y que está estrechamente relacionada con los procesos...

The nucleolus plays a pivotal role in multiple key cellular processes. An illustrative example is the regulation of mitotic exit in Saccharomyces cerevisiae through the nucleolar sequestration of the Cdc14 phosphatase. The peculiar structure of the nucleolus, however, has also its drawbacks. The repetitive nature of the rDNA gives rise to...

Understanding which intracellular signaling pathways are activated by manganese stress is crucial to decipher how metal overload compromise cellular integrity. Here, we unveil a role for oxidative and cell wall stress signaling in the response to manganese stress in yeast. We find that the oxidative stress transcription factor Yap1 protects...