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GARCIA-DIAZ , Angel

Last name: GARCIA-DIAZ

First name: Angel

September 23, 2022 (v1)

Publication

Metadata-only

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Martí, Juan Manuel Garcia-Diaz, Angel Delgado-Bellido, Daniel

Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/ activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness breast/ovarian cancer and have been shown to regulate the hypoxic response; therefore, their use could...

Uploaded on: March 24, 2023