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GASCA , Jessica

Last name: GASCA

First name: Jessica

June 20, 2017 (v1)

Publication

Metadata-only

Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer

Gasca, Jessica Flores de Mera, María de la Luz Giraldez Macias, Servando

FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins for ubiquitination and degradation by the proteasome. FBXW7 regulates cellular apoptosis by targeting MCL1 for ubiquitination. Recently, we identified PLK1 as a new substrate of FBXW7 modulating the intra-S-phase...

Uploaded on: March 25, 2023
October 9, 2020 (v1)

Publication

Metadata-only

EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells

Gasca, Jessica Flores, María Luz Jiménez Guerrero, Rocío

Epithelial–mesenchymal transition (EMT) has recently been associated with tumor progression, metastasis, and chemotherapy resistance in several tumor types. We performed a differential gene expression analysis comparing paclitaxel-resistant vs. paclitaxel-sensitive breast cancer cells that showed the upregulation of EDIL3 (EGF Like Repeats and...

Uploaded on: March 26, 2023