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GAUBERT , Alexandre

Last name: GAUBERT

First name: Alexandre

February 2023 (v1)

Journal article

Metadata-only

BRCA1/2 Pathogenic Variants Are Not Common in Merkel Cell Carcinoma: Comprehensive Molecular Study of 30 Cases and Meta-Analysis of the Literature

Gaubert, Alexandre Kervarrec, Thibault Montaudié, Henri

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine cancer. Management of advanced MCC is mainly based on immune-checkpoint inhibitors. The high failure rate warrants an investigation of new therapeutic targets. The recent identification of BRCA1 or BRCA2 (BRCA1/2) mutations in some MCC raises the issue of the use of...

Uploaded on: April 23, 2023