GAUDEL , Céline

Integration of ChIPseq and microarray data allowed to identify to our knowledge previously unreported MITF target genes, among which, the amino acid transporter, SLC7A5. We showed that siRNA-mediated SLC7A5 knock-down decreased pigmentation in B16F10 cells, without affecting morphology nor dendricity. Treatment with the SLC7A5 inhibitors BCH,...

HACE1 is an E3 ubiquitin ligase described as a tumour suppressor because HACE1-knockout mice develop multi-organ, late-onset cancers and because HACE1 expression is lost in several neoplasms, such as Wilms' tumours and colorectal cancer. However, a search of public databases indicated that HACE1 expression is maintained in melanomas. We...

Phenotypic plasticity and subsequent generation of intratumoral heterogeneity underly key traits in malignant melanoma such as drug resistance and metastasis. Melanoma plasticity promotes a switch between proliferative and invasive phenotypes characterized by different transcriptional programs of which MITF is a critical regulator. Here, we...