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May 7, 1996 (v1)Conference paperUploaded on: October 11, 2023
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February 19, 2020 (v1)Journal article
In the cell, membrane deformation and fission (collectively refered as to 'budding') is driven by specific protein machineries but is also influenced by lipid composition. We previously reported that phospholipids with polyunsaturated acyl chains facilitate membrane budding because they adapt their shape to membrane curvature, thereby...
Uploaded on: December 4, 2022 -
February 8, 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
July 28, 2008 (v1)Journal article
SUMMARY: HELIQUEST calculates the physicochemical properties and amino acid composition of an alpha -helix and screens databank to identify protein segments possessing similar features. This server is also dedicated to mutating helices manually or automatically by genetic algorithm to design analogues of defined features. AVAILABILITY:...
Uploaded on: December 4, 2022 -
November 2007 (v1)Journal article
The small G protein Rap1 regulates diverse cellular processes such as integrin activation, cell adhesion, cell-cell junction formation and cell polarity. It is crucial to identify Rap1 effectors to better understand the signalling pathways controlling these processes. Krev interaction trapped 1 (Krit1), a protein with FERM (band...
Uploaded on: December 4, 2022 -
August 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
March 15, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
February 4, 2011 (v1)Journal article
Proteins of the cytohesin/Arno/Grp1 family of Arf activators are positive regulators of the insulin-signaling pathway and control various remodeling events at the plasma membrane. Arno has a catalytic Sec7 domain, which promotes GDP to GTP exchange on Arf, followed by a pleckstrin homology (PH) domain. Previous studies have revealed two...
Uploaded on: December 3, 2022 -
February 2007 (v1)Journal article
The Golgi-associated protein ArfGAP1 has an unusual membrane-adsorbing amphipathic alpha-helix: its polar face is weakly charged, containing mainly serine and threonine residues. We show that this feature explains the specificity of ArfGAP1 for curved versus flat lipid membranes. We built an algorithm to identify other potential amphipathic...
Uploaded on: February 28, 2023 -
September 2, 2019 (v1)Journal article
A central assumption is that lipid transfer proteins (LTPs) bind transiently to organelle membranes to distribute lipids in the eukaryotic cell. Osh6p and Osh7p are yeast LTPs that transfer phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) via PS/phosphatidylinositol-4-phosphate (PI4P) exchange cycles. It...
Uploaded on: December 4, 2022 -
2014 (v1)Journal article
Late embryogenesis abundant (LEA) proteins are hydrophilic, mostly intrinsically disordered proteins, which play major roles in desiccation tolerance. In Arabidopsis thaliana, 51 genes encoding LEA proteins clustered into nine families have been inventoried. To increase our understanding of the yet enigmatic functions of these gene families, we...
Uploaded on: December 4, 2022 -
March 31, 2015 (v1)Journal article
Alpha-synuclein (AS) is a synaptic protein that is directly involved in Parkinson's disease due to its tendency to form protein aggregates. Since AS aggregation can be dependent on the interactions between the protein and the cell plasma membrane, elucidating the membrane binding properties of AS is of crucial importance to establish the...
Uploaded on: March 26, 2023 -
June 16, 2023 (v1)Journal article
Lithium (Li) has a wide range of uses in science, medicine, and industry, but its isotopy is underexplored, except in nuclear science and in geoscience. 6 Li and 7 Li isotopic ratio exhibits the second largest variation on earth's surface and constitutes a widely used tool for reconstructing past oceans and climates. As large variations have...
Uploaded on: November 25, 2023 -
June 2023 (v1)Journal article
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Uploaded on: November 25, 2023 -
August 8, 2014 (v1)Publication
Phospholipids (PLs) with polyunsaturated acyl chains are extremely abundant in a few specialized cellular organelles such as synaptic vesicles and photoreceptor discs, but their effect on membrane properties is poorly understood. Here, we found that polyunsaturated PLs increased the ability of dynamin and endophilin to deform and vesiculate...
Uploaded on: March 25, 2023 -
January 11, 2019 (v1)Journal article
Solid-state phosphor-converted white light-emitting diodes (pc-WLEDs) are currently revolutionizing the lighting industry. To advance the technology, phosphors with high efficiency, tunable photoluminescence, and high thermal stability are required. Here, we demonstrate that a simple lithium incorporation in NaAlSiO4:Eu system enables the...
Uploaded on: December 4, 2022 -
2021 (v1)Journal article
Membrane contact sites (MCS) are subcellular regions where two organelles appose their membranes to exchange small molecules, including lipids. Structural information on how proteins form MCS is scarce. We designed an in vitro MCS with two membranes and a pair of tethering proteins suitable for cryo-tomography analysis. It includes VAP-A, an ER...
Uploaded on: December 4, 2022