2020 (v1)
Publication
No description
Uploaded on: April 14, 2023
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2017 (v1)Publication
BACKGROUND: The burden of age-related chronic diseases, such as neurodegenerative disorders, led to an increasing interest in the risk factors for physical, psychological and functional decline. Frailty is a geriatric syndrome of decreased resistance to stressors and increased risk for adverse health outcomes that can be defined based on a...
Uploaded on: April 14, 2023 -
September 6, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
2023 (v1)Publication
: Traumatic stress is the main environmental risk factor for the development of psychiatric disorders. We have previously shown that acute footshock (FS) stress in male rats induces rapid and long-lasting functional and structural changes in the prefrontal cortex (PFC), which are partly reversed by acute subanesthetic ketamine. Here, we asked...
Uploaded on: January 31, 2024 -
2019 (v1)Publication
Background: Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than in late onset dementia. Objective: To identify known and/or novel rare variants in major candidate genes associated to EOD by high-throughput...
Uploaded on: October 11, 2023 -
2016 (v1)Publication
Background: Genetic testing of familial Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) is attracting interest thanks to innovative primary prevention clinical trials and increased request for information by at-risk individuals. However, ethical, social, and psychological implications are paramount and genetic testing must...
Uploaded on: March 27, 2023