GENNARELLI M.

The pathophysiological model of schizophrenia based on an NMDAR-mediated glutamate hypofunction was raised by the psychotomimetic effects induced by administration of non-competitive NMDAR antagonists. Animal models further supported this hypothesis. Functional NMDARs are composed of the ubiquitous NR1 subunit and one of four NR2 subunits. The...

Background: A consensus protocol for genetic counselling and testing of familial dementia, the Italian Dominantly Inherited Alzheimer's and Frontotemporal Network (IT-DIAfN) protocol, has been developed in Italy by a network of expert dementia centres. The aim of this study is to evaluate feasibility and acceptability of the genetic counselling...

OBJECTIVES: People with schizophrenia (SCZ) present serious and generalised deficits in social cognition (SC), which affect negatively patients' functioning and treatment outcomes. The genetic background of SC has been investigated in disorders other than SCZ providing weak and sparse results. Thus, our aim was to explore possible genetic...