GETTINGS , Melanie

What triggers a differentiated cell to naturally change its cell fate? Cell reprogramming is a rare and intriguing phenomenon, from a developmental point of view. It has been mostly involved in boundary sharpening during development, tissue regeneration and cancer. Developmental models of the understanding of pathology-related cell...

Segments are fundamental units in animal development which are made of distinct cell lineages separated by boundaries. Although boundaries show limited plasticity during their formation for sharpening, cell lineages make compartments that become tightly restricted as development goes on. Here, we characterize a unique case of breaking of the...

In Drosophila melanogaster, dorsal closure is a model of tissue morphogenesis leading to the dorsal migration and sealing of the embryonic ectoderm. The activation of the JNK signal transduction pathway, specifically in the leading edge cells, is essential to this process. In a genome-wide microarray screen, we identified new JNK target genes...