G

S

GIACHETTI , Sara

Last name: GIACHETTI

First name: Sara

September 21, 2022 (v1)

Publication

Metadata-only

Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)

Clemente, Francesca Matassini, Camilla Giachetti, Sara

We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars decorated with lipophilic chains at both the nitrogen and the adjacent carbon as potential inhibitors of the lysosomal enzyme glucocerebrosidase (GCase), which is involved in Gaucher disease. The procedure relies on the preparation of...

Uploaded on: December 4, 2022