GIL DE MONTES ROJAS , Enrique

En esta Tesis Doctoral se presentan los resultados más relevantes obtenidos del estudio de reactividad llevado a cabo sobre sistemas [2.2.1]bicíclicos (7-heteronorbornanos y 7- heteronorbornadienos), así como su aplicación en bioconjugación de proteínas. Todos los estudios llevados a cabo con sistemas bicíclicos se han efectuado con mezclas...

We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for cysteine relative to other amino acids that have nucleophilic side-chains, and the formed products are stable in human...

Aminyl radicals are nitrogen-centered radicals of interest in synthetic strategies involving C–N bond formation due to their high reactivity. These intermediate radicals are generated by the reaction of an organic azide with tributyltin hydride (Bu3SnH) in the presence of substoichiometric amounts of azobisisobutyronitrile (AIBN). In this work,...