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November 2017 (v1)Journal articleUploaded on: December 4, 2022
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January 2018 (v1)Journal article
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Uploaded on: December 4, 2022 -
August 30, 2022 (v1)Journal article
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Uploaded on: December 3, 2022 -
July 2021 (v1)Journal article
Protecting telomere from the DNA damage response is essential to avoid the entry into cellular senescence and organismal aging. The progressive telomere DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger replicative senescence and thereby contribute to aging. In several...
Uploaded on: December 3, 2022 -
May 3, 2021 (v1)Journal article
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Uploaded on: December 4, 2022 -
April 2020 (v1)Journal article
Telomeres arose from the need to stabilize natural chromosome ends, resulting in terminal chromatin structures with specific protective functions. Their constituent proteins also execute global functions within heterochromatin, where they mediate late replication and facilitate fork progression. Emerging insights into the mechanisms governing...
Uploaded on: December 4, 2022 -
September 2010 (v1)Journal article
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Uploaded on: December 4, 2022 -
1996 (v1)Journal article
Transcriptional repression at the silent mating-type loci in yeast requires the targeting of silent information regulator (Sir) proteins through specific interactions formed at cis-acting silencer elements. We show here that a reporter gene flanked by two functional silencers is not repressed when integrated at >200 kb from a telomere....
Uploaded on: December 4, 2022 -
September 4, 2012 (v1)Journal article
Transposable elements (TEs) are a major source of genetic variability in genomes, creating genetic novelty and driving genome evolution. Analysis of sequenced genomes has revealed considerable diversity in TE families, copy number, and localization between different, closely related species. For instance, although the twin species Drosophila...
Uploaded on: December 4, 2022 -
2014 (v1)Journal article
In the absence of telomerase, telomeres progressively shorten with every round of DNA replication, leading to replicative senescence. In telomerase-deficient Saccharomyces cerevisiae, the shortest telomere triggers the onset of senescence by activating the DNA damage checkpoint and recruiting homologous recombination (HR) factors. Yet, the...
Uploaded on: March 1, 2023 -
September 10, 2010 (v1)Journal article
A major issue in telomere research is to understand how the integrity of chromosome ends is controlled. Although several nucleoprotein complexes have been described at the telomeres of different organisms, it is still unclear how they confer a structural identity to chromosome ends in order to mask them from DNA repair and to ensure their...
Uploaded on: December 4, 2022 -
July 2016 (v1)Journal article
Telomere stability is a hallmark of immortalized cells, including cancer cells. While the telomere length is maintained in most cases by the telomerase, the activity of a protein complex called Shelterin is required to protect telomeres against unsuitable activation of the DNA damage response pathway. Within this complex, telomeric repeat...
Uploaded on: December 4, 2022 -
2022 (v1)Publication
Summary To obtain a proxy for the stress level of collected corals, we checked for previous occurrences of bleaching events at sampled reef sites by matching island GPS coordinates to the Reef Check dataset (reefcheck.org) obtained from Sully et al (2019). For each Tara Pacific island coordinate, we determined the Reef Check site that was...
Uploaded on: January 12, 2024 -
August 15, 2024 (v1)Journal article
Linear unconstrained DNA cannot harbor supercoils since these supercoils can diffuse and be eliminated by free rotation of the DNA strands at the end of the molecule. Mammalian telomeres, despite constituting the ends of linear chromosomes, can hold supercoils and be subjected to topological stress. While negative supercoiling was previously...
Uploaded on: November 7, 2024 -
2013 (v1)Journal article
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Uploaded on: December 4, 2022 -
March 2013 (v1)Journal article
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Uploaded on: December 4, 2022 -
February 19, 2021 (v1)Journal article
The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, shows increased nuclear localization and...
Uploaded on: December 3, 2022 -
March 2013 (v1)Journal article
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Uploaded on: December 4, 2022 -
March 2013 (v1)Journal article
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Uploaded on: February 22, 2023 -
February 27, 2009 (v1)Journal article
Both genetic and epigenetic alterations contribute to Facio-Scapulo-Humeral Dystrophy (FSHD), which is linked to the shortening of the array of D4Z4 repeats at the 4q35 locus. The consequence of this rearrangement remains enigmatic, but deletion of this 3.3-kb macrosatellite element might affect the expression of the FSHD-associated gene(s)...
Uploaded on: February 28, 2023 -
February 2024 (v1)Journal article
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Uploaded on: November 30, 2023 -
July 10, 2015 (v1)Journal article
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Uploaded on: December 4, 2022 -
August 2014 (v1)Journal article
Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of natural killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we found that the metabolic checkpoint kinase mTOR was activated and boosted bioenergetic metabolism after exposure of NK cells to high concentrations of IL-15,...
Uploaded on: December 4, 2022 -
July 15, 2014 (v1)Journal article
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Uploaded on: December 4, 2022 -
April 3, 2020 (v1)Journal article
Repressor/activator protein 1 (RAP1) is a highly evolutionarily conserved protein found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non-homologous end joining (NHEJ) and consequently telomere fusions, its role at mammalian telomeres in vivo is still controversial. Here, we demonstrate that RAP1 is required to...
Uploaded on: December 4, 2022