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GIMOND , C.

Last name: GIMOND

First name: C.

June 12, 2008 (v1)

Journal article

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Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway.

Bermudez, O. Marchetti, S. Pagès, G.

MAP kinases phosphatases (MKPs) belong to the dual-specificity phosphatase family (DUSP) and dephosphorylate phosphothreonine and phosphotyrosine within MAP kinases. We had previously shown that DUSP6/MKP-3 was phosphorylated and degraded upon growth factor stimulation, in a MEK-dependent manner. Here we show that another pathway involved in...

Uploaded on: December 4, 2022
June 2004 (v1)

Journal article

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Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice.

Marchetti, S. Gimond, C. Roux, D.

The p42/p44 mitogen activated protein kinase (MAPK) pathway participates in a wide range of cellular programs including proliferation, migration, differentiation, and survival. Specific pharmacological inhibitors, like PD98059 and U0126, are often used to inhibit p42/p44 MAPK signaling. However, these inhibitors are not appropriate to study the...

Uploaded on: December 4, 2022