G

S

GIOVANNUZZI , Simone

Last name: GIOVANNUZZI

First name: Simone

July 12, 2023 (v1)

Publication

Metadata-only

Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors

Martínez Montiel, Mónica Romero Hernández, Laura L. Giovannuzzi, Simone

The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of these metalloenzymes a hot topic in current Medicinal Chemistry. In particular, CA IX and XII are membrane-bound enzymes, responsible for tumour survival and chemoresistance. Herein, a bicyclic carbohydrate-based hydrophilic...

Uploaded on: July 13, 2023