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GOLDBERG , Mathew S

Last name: GOLDBERG

First name: Mathew S

November 2009 (v1)

Journal article

Metadata-only

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

da Costa, Cristine Alves Sunyach, Claire Giaime, Emilie

Mutations of the ubiquitin ligase parkin account for most autosomal recessive forms of juvenile Parkinson's disease (AR-JP). Several studies have suggested that parkin possesses DNA-binding and transcriptional activity. We report here that parkin is a p53 transcriptional repressor. First, parkin prevented 6-hydroxydopamine-induced caspase-3...

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