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GONÇALVES-PEREIRA , Rita

Last name: GONÇALVES-PEREIRA

First name: Rita

December 15, 2022 (v1)

Publication

Metadata-only

sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo

Schaeffer, Evelyne Sánchez Fernández, Elena Matilde Gonçalves-Pereira, Rita

Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic tail, termed sp2-iminosugar glycolipids (sp2-IGLs), target microglia during neuroinflammatory processes. Here we have synthesized and investigated new variants of sp2-IGLs for their ability to suppress the activation of...

Uploaded on: March 24, 2023