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GORE , Tanvi

Last name: GORE

First name: Tanvi

Institution: UCA

Links

March 1, 2021 (v1)

Journal article

Metadata-only

The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution

Gore, Tanvi Matusek, Tamás d'Angelo, Gisela

ABSTRACT The Hedgehog (Hh) morphogen gradient is required for patterning during metazoan development, yet the mechanisms involved in Hh apical and basolateral release and how this influences short- and long-range target induction are poorly understood. We found that depletion of the GTPase Rab8 in Hh-producing cells induces an imbalance between...

Uploaded on: December 3, 2022