G

I

GRACIA HERRERA GÓMEZ , Irene De

Last name: GRACIA HERRERA GÓMEZ

First name: Irene De

January 15, 2019 (v1)

Publication

Metadata-only

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

Mellado Gil, José Manuel Jiménez Moreno, Carmen María Martín Montalvo, Alejandro

[Aims/hypothesis]: A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular and cellular targets, would provide a means to counteract the deteriorating glycaemic control associated with diabetes mellitus. The aims of the current study were to investigate the...

Uploaded on: March 27, 2023
October 17, 2018 (v1)

Publication

Metadata-only

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity article

Mellado Gil, José Manuel Fuente Martín, Esther Lorenzo Ovejero, Petra Isabel

HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is known. Herein we demonstrate that HMG20A is...

Uploaded on: March 27, 2023