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GROSSO , Sébastien

Last name: GROSSO

First name: Sébastien

2009 (v1)

Journal article

Metadata-only

Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness.

Essafi-Benkhadir, Khadija Grosso, Sébastien Puissant, Alexandre

BACKGROUND: The ambiguous role of transcription factor Sp3 for tumour progression is still debated since it was described as a transcriptional repressor or activator. Here we tried to decipher the molecular mechanisms implicated in Sp3 accumulation observed in aggressive tumours. METHODOLOGY: We generated normal and tumour cell lines...

Uploaded on: December 3, 2022
July 2009 (v1)

Journal article

Metadata-only

Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.

Grosso, Sébastien Puissant, Alexandre Dufies, Maeva

Imatinib is used to treat chronic myelogenous leukemia (CML), but resistance develops in all phases of this disease. The purpose of the present study was to identify the mode of resistance of newly derived imatinib-resistant (IM-R) and PD166326-resistant (PD-R) CML cells. IM-R and PD-R clones exhibited an increase in viability and a decrease in...

Uploaded on: December 3, 2022