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GUÉGUINOU , Maxime

Last name: GUÉGUINOU

First name: Maxime

December 2017 (v1)

Journal article

Metadata-only

Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity

Fourbon, Yann Guéguinou, Maxime Félix, Romain

It is generally accepted that voltage-gated Ca2+ channels, CaV, regulate Ca2+ homeostasis in excitable cells following plasma membrane depolarization. Here, we show that the Ca2+ protein α1D of CaV1.3 channel is overexpressed in colorectal cancer biopsies compared to normal tissues. Gene silencing experiments targeting α1D reduced the migration...

Uploaded on: December 4, 2022
April 18, 2016 (v1)

Journal article

Metadata-only

SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline

Guéguinou, Maxime Harnois, Thomas Crottes, David

Background: Barely 10-20% of patients with metastatic colorectal cancer (mCRC) receive a clinical benefit from the use of anti-EGFR monoclonal antibodies (mAbs). We hypothesized that this could depends on their efficiency to reduce Store Operated Calcium Entry (SOCE) that are known to enhance cancer cells.Results: In the present study, we...

Uploaded on: February 28, 2023