Leptin is highly expressed in the placenta, mainly by trophoblastic cells, where it has an important autocrine trophic effect. Moreover, increased leptin levels are found in the most frequent pathology of pregnancy: gestational diabetes, where leptin may mediate the increased size of the placenta and the fetus, which becomes macrosomic. In...
-
May 20, 2021 (v1)PublicationUploaded on: March 25, 2023
-
April 21, 2023 (v1)Publication
Background and objective: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, obesity, and insulin resistance, which leads to subfertility. PCOS is the most frequent metabolic disorder in women and the major cause of infertility. Susceptibility to developing PCOS is...
Uploaded on: April 23, 2023 -
November 2, 2022 (v1)Publication
Background: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric morbidity. Methods: We conducted a multicentre prospective study in pregnancy based on a universal antenatal...
Uploaded on: March 24, 2023 -
May 20, 2021 (v1)Publication
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second...
Uploaded on: December 4, 2022 -
May 5, 2021 (v1)Publication
The placental stem cells have called the focus of attention for their therapeutic potential to treat diferent diseases, including cancer. There is plenty evidence about the antiproliferative, antiangiogenic and proapoptotic properties of the amniotic membrane. Liver cancer is the ffth cause of cancer in the world, with a poor prognosis and...
Uploaded on: December 4, 2022 -
November 21, 2022 (v1)Publication
Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson's classification model, and risk factors for cesarean...
Uploaded on: March 24, 2023