OBJECTIVES: Lipodystrophy is a major side effect of HIV protease inhibitor (PI) antiretroviral therapy. It has been shown that protease inhibitors interfere in vitro with adipocyte differentiation. However, there is no evidence that PIs accumulate into preadipocytes and adipocytes and that intra-cellular accumulation is sufficient to alter...
-
October 17, 2003 (v1)Journal articleUploaded on: December 4, 2022
-
December 8, 2000 (v1)Patent
No description
Uploaded on: December 3, 2022 -
December 8, 2000 (v1)Patent
No description
Uploaded on: October 11, 2023 -
January 21, 2005 (v1)Journal article
Lipodystrophic syndrome is a major side effect of highly active antiviral therapy. Fat tissue redistribution is associated with changes in adipocyte gene expression and in circulating levels of adipocytokines involved in the development of insulin resistance. However, the evidence that HIV drugs accumulate into human adipocytes and have a...
Uploaded on: December 4, 2022