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GUYOT , Mélanie

Last name: GUYOT

First name: Mélanie

July 19, 2013 (v1)

Publication

Metadata-only

The anti-angiogenic therapy : between hope and reality. Toward the identification of predictive markers and new therapeutic targets in renal cancer

Guyot, Mélanie

The aim of my work is to study resistance mechanisms to anti-angiogenic treatments of Clear Cell Renal Carcinoma (ccRCC). We observed that bevacizumab (BVZ) -a humanized monoclonal antibody targeting VEGF and currently used in the clinic- promotes the growth of human ccRCC xenografts in nude mice. This model mimics the "escape phase" widely...

Uploaded on: October 11, 2023