International audience
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July 1, 2020 (v1)Journal articleUploaded on: February 22, 2023
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June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: February 22, 2023 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: February 22, 2023 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: December 4, 2022 -
January 2021 (v1)Journal article
Determination of what is the specificity of subunits composing a protein complex is essential when studying gene variants on human pathophysiology. The pore-forming α-subunit KCNQ1, which belongs to the voltage-gated ion channel superfamily, associates to its β-auxiliary subunit KCNE1 to generate the slow cardiac potassium IKs current, whose...
Uploaded on: December 3, 2022 -
December 2023 (v1)Journal articleA photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are powerful methods notably used to probe the transmission of pain signals. However, costs, animal handling and ethical issues have reduced their dissemination and routine use. Here we report LAKI (Light Activated K + channel Inhibitor), a specific...
Uploaded on: March 25, 2023 -
December 2023 (v1)Journal articleA photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are powerful methods notably used to probe the transmission of pain signals. However, costs, animal handling and ethical issues have reduced their dissemination and routine use. Here we report LAKI (Light Activated K + channel Inhibitor), a specific...
Uploaded on: May 4, 2023