HÉRAULT , Joël

Introduction: In order to optimize hadrontherapy treatments, it is needed to consider the biological effect on irradiated tumor cells. The biological dose can be evaluated through biophysical models, such as the Microdosimetric Kinetic Model (MKM)[1-5]. This model is implemented to take into account a corrected lineal energy spectrum obtained...

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We investigate the proton energy loss in GaN in an energy range between 0 and 65 MeV. The energy of protons generated by a cyclotron at about 65 MeV is varied by inserting an energyabsorbing medium of varying thickness. The precise modeling of the GaN Schottky diode response as a function of the absorbing medium thickness allows us to...

We investigate the proton energy loss in GaN in an energy range between 0 and 65 MeV. The energy of protons generated by a cyclotron at about 65 MeV is varied by inserting an energy- absorbing medium of varying thickness. The precise modeling of the GaN Schottky diode response as a function of the absorbing medium thickness allows us to...

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Nowadays, proton therapy is becoming one of the most powerful technique for cancer treatment, but the throughput (number of treated patients/day) is limited thus limiting its benefits despite the high investment cost. The dose has to be calibrated very precisely, making crucial the control of the beam before irradiation. Depending on the...

We have demonstrated that GaN Schottky diodes can be used for high energy (64.8 MeV) proton detection. Such proton beams are used for tumor treatment, for which accurate and radiation resistant detectors are needed. Schottky diodes have been measured to be highly sensitive to protons, to have a linear response with beam intensity and fast...

We have demonstrated that GaN Schottky diodes can be used for high energy (64.8 MeV) proton detection. Such proton beams are used for tumor treatment, for which accurate and radiation resistant detectors are needed. Schottky diodes have been measured to be highly sensitive to protons, to have a linear response with beam intensity and fast...

International audience

International audience

International audience

Head and neck cancers, the 7 th cause of death worldwide, are currently treated with a combination of surgical resection of the primary tumor, chemotherapy and radiotherapy, depending on the disease stage. Conventional photontherapy nevertheless remains difficult to apply to tumors such as head and neck squamous cell carcinomas (HNSCC), due to...

Although chemically synthesized ferro/ferrimagnetic nanoparticles have attracted great attention in cancer theranostics, they lack radio-enhancement efficacy due to low targeting and internalization ability. Herein, we investigated the potential of RGD-tagged magnetosomes, bacterial biogenic magnetic nanoparticles naturally coated with a...

PurposeLinear energy transfer (LET) plays an important role in radiation response. Recently, the radiation-induced nucleo-shuttling of ATM from cytoplasm to the nucleus was shown to be a major event of the radiation response that permits a normal DNA double-strand break (DSB) recognition and repair. Here, we aimed to verify the relevance of the...

En 2006, l'Institut national du cancer a lancé un appel d'offres portant sur la radiothérapie stéréotaxique extracrânienne. Trois sites (Lille, Nancy et Nice) ont été sélectionnés pour implanter et évaluer un robot de radiothérapie, le CyberKnife®. Cette machine capable de suivre des tumeurs mobiles en temps réel ouvre de nouvelles perspectives...

We propose a novel prompt-gamma (PG) imaging modality for real-time monitoring in proton therapy: PG time imaging (PGTI). By measuring the time-of-flight (TOF) between a beam monitor and a PG detector, our goal is to reconstruct the PG vertex distribution in 3D. In this paper, a dedicated, non-iterative reconstruction strategy is proposed (PGTI...

Abstract We recently proposed a new approach for the real-time monitoring of particle therapy treatments with the goal of achieving high sensitivities on the particle range measurement already at limited counting statistics. This method extends the Prompt Gamma (PG) timing technique to obtain the PG vertex distribution from the exclusive...