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HABIF , Guillaume

Last name: HABIF

First name: Guillaume

September 2017 (v1)

Journal article

Metadata-only

Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer

Prieur, Alexandre Cappellini, Monica Habif, Guillaume

Patients with metastatic colorectal cancer suffer from disease relapse mainly due to cancer stem cells (CSC). Interestingly, they have an increased level of blood progastrin, a tumor-promoting peptide essential for the self-renewal of colon CSCs, which is also a direct β-catenin/TCF4 target gene. In this study, we aimed to develop a novel...

Uploaded on: February 27, 2023