The bone is a highly dynamic organ controlled by osteoclasts (OCL), a unique cell capable to resorb bone, working in concert with bone-forming osteoblasts to maintain bone remodeling and skeletal homeostasis throughout life. OCLs are myeloid cells, a family of innate immune cells characterised by a high heterogeneity and polarization...
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September 22, 2023 (v1)PublicationUploaded on: January 10, 2024
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May 13, 2020 (v1)Journal article
Bone destruction relies on interactions between bone and immune cells. Boneresorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the presence of inflammatory OCLs...
Uploaded on: December 4, 2022 -
January 4, 2021 (v1)Publication
Increased myelopoiesis is a hallmark of many chronic inflammatory diseases. However, the mechanisms involved in the myeloid skewing of hematopoiesis upon inflammation are still incompletely understood. Here, we identify an unexpected role of bone-resorbing osteoclasts in promoting hematopoietic stem cell (HSC) proliferation and differentiation...
Uploaded on: December 4, 2022 -
2023 (v1)Journal article
Bone destruction is a hallmark of chronic inflammation, and bone-resorbing osteoclasts arising under such a condition differ from steady-state ones. However, osteoclast diversity remains poorly explored. Here, we combined transcriptomic profiling, differentiation assays and in vivo analysis in mouse to decipher specific traits for inflammatory...
Uploaded on: May 6, 2023