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HAN , Shuanglin

Last name: HAN

First name: Shuanglin

October 26, 2022 (v1)

Publication

Metadata-only

Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the fibroblast growth factor 21 locus

Bayoumi, Ali Elsayed, Asmaa Han, Shuanglin

Fibroblast growth factor 21 (FGF21) is a liver-derived hormone with pleiotropic beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic diseases. Interventions that restore metabolic homeostasis reduce FGF21. Whether abnormalities in FGF21 secretion or resistance in peripheral tissues is the initiating factor in...

Uploaded on: December 4, 2022