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HAOUZ , Ahmed

Last name: HAOUZ

First name: Ahmed

January 2022 (v1)

Journal article

Metadata-only

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain

Fagnen, Charline Bannwarth, Ludovic Oubella, Iman

ATP-sensitive potassium (K-ATP) channels are ubiquitously expressed on the plasma membrane of cells in several organs, including the heart, pancreas, and brain, and they govern a wide range of physiological processes. In pancreatic β-cells, K-ATP channels composed of Kir6.2 and SUR1 play a key role in coupling blood glucose and insulin...

Uploaded on: December 3, 2022
March 1, 2020 (v1)

Journal article

Metadata-only

PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients

Pothlichet, Julien Rose, Thierry Bugault, Florence

The precise mechanism leading to profound immunodeficiency of HIV-infected patients is still only partially understood. Here, we show that more than 80% of CD4+ T cells from HIV-infected patients have morphological abnormalities. Their membranes exhibited numerous large abnormal membrane microdomains (aMMDs), which trap and inactivate...

Uploaded on: December 4, 2022