HARARI , Óscar

Biomedical research has been revolutionized by high-throughput techniques and the enormous amount of biological data they are able to generate. The interest shown over network models and systems biology is rapidly raising. Genetic networks arise as an essential task to mine these data since they explain the function of genes in terms of how...

A critical challenge of the postgenomic era is to understand how genes are differentially regulated in and between genetic networks. The fact that such co-regulated genes may be differentially regulated suggests that subtle differences in the shared cis-acting regulatory elements are likely significant, however it is unknown which of these...

The increased availability of biological databases contain ing representations of complex objects permits access to vast amounts of data. In spite of the recent renewed interest in knowledge-discovery tech niques (or data mining), there is a dearth of data analysis methods in tended to facilitate understanding of the represented objects and...

The rapid development of methods that select over/under expressed genes from microarray experiments have not yet matched the need for tools that identify informational profiles that differentiate between experimental condi tions such as time, treatment and phenotype. Uncertainty arises when methods devoted to identify significantly expressed...

One of the biggest challenges in genomics is the elucidation of the design principles controlling gene expression. Current approaches examine promoter sequences for particular features, such as the presence of binding sites for a transcriptional regulator, and identify recurrent relationships among these features termed network motifs. To...

A critical challenge of the postgenomic era is to understand how genes are differentially regulated even when they belong to a given network. Because the fundamental mechanism controlling gene expression operates at the level of transcription initiation, computational techniques have been devel oped that identify cis-regulatory features and...

Genetic and genomic approaches have been used successfully to assign genes to distinct regulatory networks, but the uncertainty concerning the connec tions between genes, the ambiguity inherent to the biological processes, and the impossibility of experimentally determining the underlying biological properties only allow a rough prediction of...