HENLEY , Beverly M.

During mammalian central nervous system (CNS) development, an enormous variety of cell types are generated. This cell diversity is due in part to asymmetrical cell division. Asymmetrical segregation of Numb, a cell-determinant protein, can result in the differential activation of the Notch pathway. The Notch pathway defines one of the few...

During mammalian central nervous system development, an enormous variety of cell types are generated. This cell diversity is due in part to asymmetrical cell division. Indeed, in some sense Notch signals link the fate decisions of one cell to those of its neighbours. This fundamental signalling pathway has not yet been modeled within membrane...