HERAS GARVÍN , Antonio

Introducción La microglía es un tipo de célula de soporte neuronal (neuroglía) presente en el sistema nervioso central de vertebrados e invertebrados cuya función principal es actuar como célula inmune. Como su nombre sugiere se trata de células de pequeño tamaño, las más pequeñas de toda la neuroglía. Durante muchos años su función no estuvo...

Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly known. We have studied the post-transcriptional changes in the proteome of mammalian cells elicited by acute hypoxia and found that phosphorylation of eukaryotic elongation factor 2 (eEF2), a ribosomal translocase whose...

Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number of in vitro and in vivo studies have reported that hypoxia can induce amyloid-β peptide accumulation through various molecular mechanisms including the up-regulation of the amyloid-β precursor protein, the β-secretase Bace1,...