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HUERTAS CASTAÑO , Carlos

Last name: HUERTAS CASTAÑO

First name: Carlos

February 17, 2020 (v1)

Publication

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Hypoxia in the Initiation and Progression of Neuroblastoma Tumours

Huertas Castaño, Carlos Gómez Muñoz, María Ángeles Pardal Redondo, Ricardo

Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a...

Uploaded on: March 25, 2023
December 1, 2022 (v1)

Publication

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Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination

Orta Vázquez, Manuel Luis Pastor Carrillo, Nuria María Burgos Morón, Estefanía

Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that preferentially target cancer cells. It acts primarily as a trap for DNA methyl transferases (DNMTs) protein by forming covalent complexes between DNMT protein and zebularine-substrate DNA. It's well documented that...

Uploaded on: March 24, 2023