HUHLE , R.

In experimental elastase-induced emphysema, mechanical ventilation with variable tidal volumes (VT) set to 30% coefficient of variation (CV) may result in more homogenous ventilation distribution, but might also impair right heart function. We hypothesized that a different CV setting could improve both lung and cardiovascular function....

Background Variable ventilation improves respiratory function, but it is not known whether the amount of variability in tidal volume (V T ) can be reduced in recruited lungs without a deterioration of respiratory system elastance. Methods Acute lung inflammation was induced by intratracheal instillation of lipopolysaccharide in 35 Wistar rats....

Background: Experimental studies showed that controlled variable ventilation (CVV) yielded better pulmonary function compared to non-variable ventilation (CNV) in injured lungs. We hypothesized that CVV improves intraoperative and postoperative respiratory function in patients undergoing open abdominal surgery. Methods: Fifty patients planned...