H

R

HURTADO GUERRERO , Ramón

Last name: HURTADO GUERRERO

First name: Ramón

March 9, 2022 (v1)

Publication

Metadata-only

NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery

García García, Ana Hicks, Thomas El Qaidi, Samir

NleB/SseK effectors are arginine-GlcNAc-transferases expressed by enteric bacterial pathogens that modify host cell proteins to disrupt signaling pathways. While the conserved Citrobacter rodentium NleB and E. coli NleB1 proteins display a broad selectivity towards host proteins, Salmonella enterica SseK1, SseK2, and SseK3 have a narrowed...

Uploaded on: March 25, 2023
April 7, 2021 (v1)

Publication

Metadata-only

Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity

Latorre Muro, Pedro Baeza, Josue Hurtado Guerrero, Ramón

Acetylation is known to regulate the activity of cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme in gluconeogenesis, by promoting the reverse reaction of the enzyme (converting phosphoenolpyruvate to oxaloacetate). It is also known that the histone acetyltransferase p300 can induce PCK1 acetylation in cells, but whether that is...

Uploaded on: December 4, 2022