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HYPOLITE , Guillaume

Last name: HYPOLITE

First name: Guillaume

November 15, 2024 (v1)

Journal article

Metadata-only

ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development.

Andrieu, Guillaume Hypolite, Guillaume Latiri, Mehdi

Alterations inactivating the tumor suppressor gene PTEN drive the development of solid and hematological cancers, such as T-cell acute lymphoblastic leukemia (T-ALL), whereby PTEN loss defines poor-prognosis patients. We investigated the metabolic rewiring induced by PTEN loss in T-ALL, aiming at identifying novel metabolic vulnerabilities. We...

Uploaded on: April 4, 2025