I. MELLONI

The calpain/calpastatin proteolytic system regulates several physiopathological processes and can play opposing roles in cancer. New strategies to control alterations ofthis system for therapeutic purposes require a full understanding of the functional role played by the single protein members. For this purpose we have evaluated theinvolvement...

BACKGROUND: Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma) experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting. We noticed that our...