IVALDO , Caterina

Cadherin superfamily is a major component of adherens junctions' (AJs) core, in epithelial and endothelial tissues. It has been shown that under apoptosis and calcium influx, metalloproteinases (MMPs) work in concert with the enzyme γ-secretase to disassemble adherens junctions. At the molecular level, MMPs and γ-secretase act by directly...

Heme oxygenase 1 (HO-1) is crucially involved in cell adaptation to oxidative stress and has been demonstrated to play an important role in cancer progression and resistance to therapies. We recently highlighted that undifferentiated neuroblastoma (NB) cells are prone to counteract oxidative stress through the induction of HO-1. Conversely,...