IGLESIAS BLANCO , Nieves

Actualmente existen numerosas enfermedades que ponen en peligro la salud de la población y en paralelo, han entrado en juego distintas estrategias terapéuticas para combatirlas. Como en numerosas ocasiones, la naturaleza ha servido de inspiración: dado que la respuesta a estímulos es un proceso básico de los sistemas vivos, se han diseñado...

La esperanza de vida en Andalucía y en España ha crecido de manera constante durante los últimos 20 años y, en 2017, presentaron valores cercanos a 86 y 80 años para mujeres y hombres, respectivamente. Esta tendencia es la misma que la observada en otros países desarrollados. Sin embargo, a pesar de las grandes inversiones que se realizan en la...

This study investigates the impact of dual ionic and covalent cross-links (ion-XrL and cov-XrL) on the properties of chitosan-based (CTS) hydrogels as eco-friendly drug delivery systems (DDS) for the model drug diclofenac sodium (DCNa). Citric acid and a diiodo-trehalose derivative (ITrh) were the chosen ionic and covalent cross-linker,...

In recent years, the preparation of valuable drug delivery systems (DDS) from self-assembled amphiphilic copolymers has attracted much attention since these nanomaterials provide new opportunities to solve problems such as the lack of solubility in water of lipophilic drugs, improve their bioavailability, prolong their circulation time and...

The present work describes the preparation of stable organic nanoparticles with potential use as "smart" drug delivery systems capable of encapsulating lipophilic molecules to exert their therapeutic action under the appropriate stimulus. A well-defined self-assembly hydrophilichydrophobic di-block copolymer has been synthesized via atom...

The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must...

NMR, ATR-FTIR and Mass Spectra of small molecules and monomers: {1-[3,5-bis(trifluoromethyl)phenyl]-3-cyclohexylthiourea} (TU) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS 3-(Prop-2-yn-1-ylthio)-propane-1,2-diol (1) 1H NMR, COSY, 13C NMR, HSQC, ATR-FTIR, ESI-MS, ESI-HRMS 4-[(Prop-2-yn-1-ylthio)methyl]-1,3-dioxolan-2-one (2) ...