I

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II , Hiromi

Last name: II

First name: Hiromi

October 21, 2011 (v1)

Journal article

Metadata-only

Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.

Jemel, Ikram Ii, Hiromi Oslund, Rob C

Among mammalian secreted phospholipases A(2) (sPLA(2)s), group X sPLA(2) has the most potent hydrolyzing activity toward phosphatidylcholine and is involved in arachidonic acid (AA) release. Group X sPLA(2) is produced as a proenzyme and contains a short propeptide of 11 amino acids ending with a dibasic motif, suggesting cleavage by proprotein...

Uploaded on: December 4, 2022