International audience
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September 2020 (v1)Journal articleUploaded on: December 4, 2022
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April 2019 (v1)Journal article
Histopathology is the fundamental tool of pathology used for more than a century to establish the final diagnosis of lung cancer. In addition, the phenotypic data contained in the histological images reflects the overall effect of molecular alterations on the behavior of cancer cells and provides a practical visual reading of the aggressiveness...
Uploaded on: December 4, 2022 -
May 1, 2011 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
January 1, 2021 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
July 31, 2020 (v1)Journal article
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Uploaded on: December 3, 2022 -
2019 (v1)Journal article
Tumor mutational burden (TMB) has emerged as an important potential biomarker for prediction of response to immune-checkpoint inhibitors (ICIs), notably in non-small cell lung cancer (NSCLC). However, its in-house assessment in routine clinical practice is currently challenging and validation is urgently needed. We have analyzed sixty NSCLC and...
Uploaded on: December 4, 2022 -
2021 (v1)Journal article
Background: Detection of genomic rearrangements, like anaplastic lymphoma kinase (ALK) fusions, is a pivotal requirement in non-small cell lung cancer (NSCLC) for the initiation of a targeted treatment. While tissue testing remains the gold standard, detection of these alterations using liquid biopsies is an unmet need. To enable the detection...
Uploaded on: December 4, 2022 -
June 29, 2018 (v1)Journal article
Lung cancer is the major cause of death from cancer in the world and its incidence is increasing in women. Despite the progress made in developing immunotherapies and therapies targeting genomic alterations, improvement in the survival rate of advanced stages or metastatic patients remains low. Thus, urgent development of effective therapeutic...
Uploaded on: December 4, 2022 -
November 14, 2019 (v1)Journal article
Lung cancer is the leading cause of cancer death worldwide, with poor prognosis and a high rate of recurrence despite early surgical removal. Hypoxic regions within tumors represent sources of aggressiveness and resistance to therapy. Although long non-coding RNAs (lncRNAs) are increasingly recognized as major gene expression regulators, their...
Uploaded on: February 22, 2023 -
November 14, 2019 (v1)Journal article
Lung cancer is the leading cause of cancer death worldwide, with poor prognosis and a high rate of recurrence despite early surgical removal. Hypoxic regions within tumors represent sources of aggressiveness and resistance to therapy. Although long non-coding RNAs (lncRNAs) are increasingly recognized as major gene expression regulators, their...
Uploaded on: December 4, 2022 -
August 2022 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
2022 (v1)Journal article
Introduction: Gene fusion testing of ALK, ROS1, RET, NTRK, and MET exon 14 skipping mutations is guideline recommended in nonsquamous NSCLC (NS-NSCLC). Nevertheless, assessment is often hindered by the limited availability of tissue and prolonged next-generation sequencing (NGS) testing, which can protract the initiation of a targeted therapy....
Uploaded on: March 7, 2024