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IMBRIGLIO , Tiziana

Last name: IMBRIGLIO

First name: Tiziana

2023 (v1)

Publication

Metadata-only

mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data

Celli, Roberta Striano, Pasquale Citraro, Rita

Background Previous studies suggest that different metabotropic glutamate (mGlu) receptor subtypes are potential drug targets for treating absence epilepsy. However, no information is available on mGlu3 receptors. Objective To examine whether (i) changes of mGlu3 receptor expression/signaling are found in the somatosensory cortex and thalamus...

Uploaded on: February 4, 2024
2017 (v1)

Publication

Metadata-only

Alterations in the alfa(2) gamma ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies

Santolini, Ines Celli, Roberta Cannella, Milena

Objectives: Thrombospondins, which are known to interact with the α2δ subunit of voltage-sensitive calcium channels to stimulate the formation of excitatory synapses, have recently been implicated in the process of epileptogenesis. No studies have been so far performed on thrombospondins in models of absence epilepsy. We examined whether...

Uploaded on: April 14, 2023